Category: Toxicology

FOAM of the Week – Intracranial Hemorrhage, Benzo Equivalents, Calcium Channel and Beta Blocker Toxicity

Some great FOAM stuff related to this week’s topics: Evidence behind BP reduction after ICH: http://pulmccm.org/main/2013/randomized-controlled-trials/in-intracerebral-hemorrhage-rapid-blood-pressure-reductions-were-safe-interact2/ Benzo Equivalent dosing calculator: http://www.globalrph.com/benzodiazepine_calc.htm Calcium Channel and Beta Blocker Toxicity review podcast (peds focused, but generalizable): http://www.pemed.org/blog/2013/4/15/calcium-channel-blockers-beta-blockers-and-undifferentiated.html

FOAM of the Week – EtOH Withdrawal, Cannabinoid Hyperemesis Syndrome, Depakote Toxicity

More tox FOAM stuff from this week: A couple podcasts from EMRAP covering both treatment of severe EtOH withdrawal as well out outpatient treatment of mild EtOH withdrawal: https://www.emrap.org/episode/nov/alcohol https://www.emrap.org/episode/thepsychiatryof/alcohol Phenobarb monotherapy for EtOH withdrawal: http://emcrit.org/pulmcrit/phenobarbital-monotherapy-for-alcohol-withdrawal-simplicity-and-power/ Overview of cannabinoid hyperemesis syndrome from LITFL: http://lifeinthefastlane.com/therapeutic-showering/ Finally, overview of valproic acid toxicity: http://www.aliem.com/valproic-acid-induced-hyperammonemic-encephalopathy/

FOAM of the Week – Chemical Terrorism, NOAC Reversal, Necrotizing Soft Tissue Infections

Continuing our tox topics this week, as well anticoagulation reversal and Nec Fasc: A timely overview on chemical, biological, radioactive and nuclear threats from St Emlyns, including info on irritant gases, nerve agents, and vessicants: http://stemlynsblog.org/cbrn-an-introduction/ Learn about the literature behind Praxbind: http://rebelem.com/noreversaban/ Look out for Andexanet Alfa on the horizon: http://www.emlitofnote.com/2015/11/the-great-reveal-of-andexanet-alfa.html Overview of Nec Fasc including the …

Continue reading

FOAM of the Week – Drug-Induced Seizures, Iron Toxicity, Serotonin Syndrome and NMS

Back from the holidays with some great tox subjects: New onset or refractory seizures?  Think tox!  Check out this review of toxicologic causes of seizures from LITFL: http://lifeinthefastlane.com/toxicology-conundrum-023/ Review of iron toxicity from ALIEM: http://www.aliem.com/management-iron-toxicity/ Overview of Serotonin syndrome and NMS from EmDocs: http://www.emdocs.net/serotonin-syndrome-and-neuroleptic-malignant-syndrome-pearls-pitfalls/